Proton Pump Inhibitors & Barrett’s Esophagus
Video course: 1.0 credit hours (pharmacy) from NANCEAC
NANCEAC is ND certification for all US States and Canadian Provinces. Learn more about this certification here.
Finally understand the back-and-forth guidelines and evidence
This CEU course is a review and critical appraisal of recent clinically relevant research on PPI use in those with Barrett’s Esophagus. The studies we specifically critically review are below:
Chen Y, Sun C, Wu Y, Chen X, Kailas S, Karadsheh Z, Li G, Guo Z, Yang H, Hu L, Zhou Q. Do proton pump inhibitors prevent Barrett’s esophagus progression to high-grade dysplasia and esophageal adenocarcinoma? An updated meta-analysis. J Cancer Res Clin Oncol. 2021 Sep;147(9):2681-2691. doi: 10.1007/s00432-021-03544-3. Epub 2021 Feb 11. PMID: 33575855.
Hu Q, Sun TT, Hong J, Fang JY, Xiong H, Meltzer SJ. Proton Pump Inhibitors Do Not Reduce the Risk of Esophageal Adenocarcinoma in Patients with Barrett’s Esophagus: A Systematic Review and Meta-Analysis. PLoS One. 2017 Jan 10;12(1):e0169691. doi: 10.1371/journal.pone.0169691. PMID: 28072858; PMCID: PMC5224998.
Shaheen, Nicholas J. MD, MPH1; Falk, Gary W. MD, MS2; Iyer, Prasad G. MD, MS3; Souza, Rhonda F. MD4; Yadlapati, Rena H. MD, MHS (GRADE Methodologist)5; Sauer, Bryan G. MD, MSc (GRADE Methodologist)6; Wani, Sachin MD7 Diagnosis and Management of Barrett’s Esophagus: An Updated ACG Guideline, The American Journal of Gastroenterology: April 2022 – Volume 117 – Issue 4 – p 559-587
Singh S, Garg SK, Singh PP, Iyer PG, El-Serag HB. Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett’s oesophagus: a systematic review and meta-analysis. Gut. 2014 Aug;63(8):1229-37. doi: 10.1136/gutjnl-2013-305997. Epub 2013 Nov 12. PMID: 24221456; PMCID: PMC4199831.
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Learning Objectives
- Recall the pathophysiology of the progression of Barrett’s esophagus to adenocarcinoma
- Implement the 2022 ACG guidelines on the use of PPIs for Barrett’s esophagus
- Evaluate the conclusions from the three competing meta-analyses on PPIs for Barrett’s
- Apply relative risk reduction calculations to the determination of the benefit of PPIs for Barrett’s
